WebMar 21, 2024 · In particular, the representative cell proliferation marker (MKI67), proliferative cell nuclear antigen (PCNA), 39 DNA topoisomerase II alpha (TOP2A), a baculoviral inhibitor of apoptosis repeat-containing protein 5 (BIRC5/Survivin), 14 master regulator of cell proliferation, forkhead box M1 (FOXM1), 40 E2F family, 41 and cyclin … WebWe found robust expression of Mki67 and other markers of proliferation (Anln, Aurka, Birc5, Pcna, and Plk1) used by Soonpaa et al. in neonatal cardiomyocytes (Fig. 3G), in agreement with our bulk mRNA-sequencing data (Fig. 1F). However, expression of these proliferation markers was largely negligible in adult cardiomyocytes (Fig. 1F).
DEPDC1B regulates the progression of human chordoma through …
WebJan 7, 2024 · BIRC5, on the contrary, is commonly considered an anti-apoptotic molecule, promoting cell division and tumor progression and it is widely regarded as potential therapeutic target. ... Importantly, cell proliferation upon genetic disruption is dramatically reduced, as demonstrated by a 90% reduction in radioactive-thymidine incorporation . … WebDec 12, 2012 · Using BIRC5- or BCL2L1-specific shRNAs (Figure 4SA, B), we found that depletion of BIRC5 or BCL2L1 impaired the proliferation and AI growth of β-catenin-dependent cell lines (Figure 4A, B). These observations corroborate recent observations that cancer cell lines that harbor activating mutations in β-catenin are particularly sensitive to ... oh may i join the choir invisible
BIRC5 is a prognostic biomarker associated with tumor
WebMar 21, 2024 · Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:9859993, 21364656, ... (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; in the complex forms a triple-helix bundle-based subcomplex with INCENP and CDCA8 (PubMed:17956729). … WebIntroduction: Human Baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5) which encodes survivin exhibits multiple biological activities, such as cell proliferation and apoptosis. WebCell proliferation and apoptosis were measured by MTT assay and flow cytometry, respectively. Results: We have successfully knocked out the BIRC 5 gene in these … my husband is hiding alcohol