Shuttling factors
WebIt is noteworthy that another proteasome shuttling factor, UBQLN2, with similarities to RAD23B, also uses its multiple domains to undergo LLPS and association with stress granules in the cytoplasm 52. WebNov 1, 2002 · Also, it is unclear what transport receptors are needed to recycle shuttling factors (including NMD3) back into the nucleus. It will be interesting to learn whether export of 40S subunits is mediated by a system comparable to the one described here, or if an intrinsic ribosomal protein directs export.
Shuttling factors
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WebModulation of the frequency of phosphorylation and shuttling cycles has recently also been reported for the yeast transcription factor Crz1 (Cai et al. 2008) and might therefore be a more general mechanism of transcription regulation in response to stimuli. WebThe transcription factor Smad2 is released from cytoplasmic retention by TGFβ receptor-mediated phosphorylation, accumulating in the nucleus where it associates with cofactors to regulate transcription. We uncovered direct interactions of Smad2 with the nucleoporins CAN/Nup214 and Nup153. These interactions mediate constitutive nucleocytoplasmic …
WebApr 1, 2024 · mRNA level is controlled by factors that mediate both mRNA synthesis and decay, including the exonuclease Xrn1 - a major mRNA synthesis and decay factor. Here we show that nucleocytoplasmic shuttling of Xrn1 and of some of its associated mRNA decay factors plays a key role in determining both mRNA synthesis and decay. Shuttling is …
WebJun 8, 2001 · A role for shuttling proteins in coupling splicing to mRNA export has been recently demonstrated [46], [47]. The shuttling protein REF1-I or Aly is a member of the REF family of evolutionary conserved hnRNP-like proteins (see [48] and references therein). The yeast homologue of Aly is the mRNA export factor Yra1p. WebAlthough several proteasome subunits have been shown to bind ubiquitin chains, many ubiquitylated substrates also associate with 26S proteasomes via "shuttling factors." …
WebContrary to this assumption, it was demonstrated that STATs are constantly shuttling between nucleus and cytoplasm ... Nucleocytoplasmic shuttling of STAT transcription …
WebMay 12, 2024 · Dysregulation of shuttling proteins leads to mislocalization of proteins, which is relevant to several diseases. It has been reported that more and more shuttling proteins such as transcription factors, cell cycle regulators and other functional proteins are also found in a variety of diseases. raymarine offers ukWebThe goal of this Special Issue (SI) is to bring together reviews and manuscripts on shuttling factors with both nuclear and cytoplasmic functions in gene expression. The biochemical, … simplicity 1453WebUnspliced, genomic HIV-1 RNA (vRNA) is a component of several ribonucleoprotein complexes (RNP) during the viral replication cycle. In earlier work, we demonstrated that the host upframeshift protein 1 (UPF1), a key factor in nonsense-mediated mRNA decay (NMD), colocalized and associated to the viral structural protein Gag during viral egress. In this … simplicity 1466WebTo investigate a possible involvement of Ran and other nucleocytoplasmic shuttling factors in nuclear export in our assay, we analyzed the stimulation of nuclear export of … simplicity 1465WebOct 3, 2024 · Interestingly, factors involved in decapping, the event that directly precedes Xrn1 attack during basal mRNA decay, were selectively increased in the nuclei of cells lacking Xrn1. Furthermore, we detected increased levels of the NMD factor UPF1 in the cytoplasm and overall elevated levels of GW182 in these cells. raymarine outletWebCartwright, P., & Helin*, K. (2000). Nucleocytoplasmic shuttling of transcription factors. Cellular and Molecular Life Sciences, 57(8), 1193–1206. doi:10.1007 ... simplicity 1449WebApr 1, 2024 · Here we show that nucleocytoplasmic shuttling of Xrn1 and of some of its associated mRNA decay factors plays a key role in determining both mRNA synthesis and decay. Shuttling is regulated by RNA-controlled binding of the karyopherin Kap120 to two nuclear localization sequences (NLSs) in Xrn1. raymarine official site